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Laboratory tests were viewed retrospectively in three groups of patients: The mean ratio was midway in the S group.

However, high alcohol consumption as a cause for abnormal liver test results is often not evident and may even be denied. A readily obtainable blood test to reveal whether alcohol is the likely AST Adv! 2000 would be valuable. Several markers for high alcohol consumption per se have been studied e.

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Most have fairly low sensitivities and specificities Conigrave et al. The use of test combinations significantly improves the information received with single serum enzyme AST Adv! 2000. An elevated serum AST in relation to serum ALT alanine aminotransferase has been proposed as an indicator that alcohol has induced organ damage.

The De Ritis Ratio: The Test of Time

One such factor may be the severity of the liver disease. METHODS This study was performed on records of patients with high alcohol AST Adv! 2000 in whom liver tests data had been collected on admission to hospital. Group W consisted of patients men and 59 womenmean age 46 years range 19—81 yearsconsecutively admitted to an alcohol and drug treatment unit at a psychiatric department of the University Hospital AST Adv! 2000 management of alcohol withdrawal W.

All these patients fulfilled DSM-IV criteria for alcohol dependence American Psychiatric Association, and showed withdrawal symptoms of AST Adv! 2000 a degree of severity that in-patient treatment was considered necessary. Patients who had severe somatic complications also due to their alcohol dependence, necessitating treatment in medical wards, were excluded. The W patients were considered to represent AST Adv! 2000 alcohol dependence with a need for repeated in-patient treatment for alcohol withdrawal.

They had consumed high amounts of alcohol for a comparatively short period, or somewhat smaller amounts for prolonged periods. Most of AST Adv! 2000 patients in this group had been consuming alcohol until the day of admission.

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Data on AST Adv! 2000 alcohol consumption were obtained by interview. Group S comprised 78 patients 67 men and 11 women with mean age of 53 years, range 23—85 years with alcohol abuse or dependence, admitted to surgical or medical wards, with a wide range of different somatic S diseases e.

Requests to do so should be addressed to the Editor. While initially described as a characteristic of acute viral hepatitis AST Adv! 2000 ALT was usually higher than AST, other authors have subsequently found it useful in alcoholic hepatitis, where AST is usually higher than ALT.

The De Ritis Ratio: The Test of Time

These interpretations are far too simplistic however as acute viral hepatitis can have AST greater than ALT, and this can be a sign of fulminant disease, while alcoholic hepatitis can have ALT greater than AST when several days have elapsed since alcohol exposure. The ratio therefore represents the time course and aggressiveness of disease that would be predicted from the relatively short half-life of AST 18 h compared to ALT 36 h. There are methodological issues, AST Adv! 2000 whether or not pyridoxal phosphate is used in the transaminase assays, and although this can have specific effects when patient samples are deficient in this vitamin, these method differences generally have mild effects on the usefulness of the assays or the ratio.

Ideally laboratories should be using pyridoxal phosphate supplemented assays in alcoholic, elderly and cancer patients who may be pyridoxine deplete. The ratio of the serum activities of AST and ALT was first described by . but a high AST/ALT ratio is suggestive of either recent exposure or advanced alcoholic. TXT, SOFTWARE BULLETIN #B,AST-VGA PLUS UTILITIES TXT, AST Adv! 2000 BULLETIN #,Server Advanced Diags, Version .



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